Watch Intently (three)pentobarbital will lessen the extent or effect of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Solid or reasonable CYP3A4 inducers may perhaps maximize price of diazepam elimination; consequently, efficacy of diazepam could possibly be lowered.
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pentobarbital will lessen the extent or impact of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
fentanyl intranasal and pentobarbital both boost sedation. Keep away from or Use Alternate Drug. Restrict use to people for whom alternate remedy solutions are inadequate
pentobarbital will lower the extent or result of saxagliptin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
pentobarbital will minimize the level or result of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Psychological, tolerance and physical dependence may well take place with continued use; sufferers with psychological dependence on barbiturates might establish a Actual physical dependence on barbiturates by raising or decreasing the dosage interval with out consulting a medical doctor
pentobarbital will lower the extent or outcome of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital increases toxicity of methoxyflurane by escalating metabolism. Contraindicated. Improved metabolism of methoxyflurane to nephrotoxic compounds.
Pentobarbital continues to be used or considered as a substitute to the barbiturate sodium thiopental utilized for money punishment by lethal injection in the United States when that drug became unavailable.[16] In 2011 the U.S. company of sodium thiopental stopped generation, and importation on the drug proved extremely hard.
pentobarbital will minimize the level or impact of cannabidiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Consider an increase in cannabidiol dosage (depending on medical reaction and tolerability) when coadministered with a solid CYP3A4 inducer.
pentobarbital will minimize the extent or influence of tacrolimus by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will reduce the extent or influence of tolterodine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
buprenorphine transdermal and pentobarbital both increase sedation. get more info Keep away from or Use Alternate Drug. Restrict use to patients for whom different procedure choices are inadequate